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Human IgE antibody-forming cells. Radio-resistant and radio-sensitive subpopulations.
In vitro IgE and antimite IgE antibody (IgE Ab) synthesis was investigated. Peripheral blood lymphocytes (PBL) from atopic patients depleted of E-rosetting T cells developed IgE and IgE Ab in the absence of pokeweed mitogen (PWM), and it was not significantly affected by addition of T cells of of PWM. 1,000 R irradiation decreased more than 50% of the IgE and IgE Ab-producing capacity in 2 of 8 cases, but the remainder were not significantly affected. Increase of the gamma-ray dose from 1,000 to 12,000 R did not result in more suppression. Radio-resistant as well as radio-sensitive subpopulations may exist in the PBL of atopic patients. The radio-sensitive component of IgE and IgE Ab formation was suppressed by PWM, while the radio-resistant component was not affected.
PMID: 6971813 [PubMed - indexed for MEDLINE]
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Cited by 3 PubMed Central articles
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In vitro production of IgE by human peripheral blood mononuclear cells. IV. Modulation by allergen of the spontaneous IgE antibody biosynthesis.
Romagnani S, Maggi E, Del Prete GF, Almerigogna F, Biagiotti R, Giudizi MG, Ricci M.
Clin Exp Immunol. 1982 Jul; 49(1):185-92.
[Clin Exp Immunol. 1982]
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In vitro synthesis of IgE by human peripheral blood leucocytes. III. Release of pre-formed antibody.
Turner KJ, Holt PG, Holt BJ, Cameron KJ.
Clin Exp Immunol. 1983 Feb; 51(2):387-94.
[Clin Exp Immunol. 1983]
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In vitro production of IgE by human peripheral blood mononuclear cells. III. Demonstration of a circulating IgE-bearing cell involved in the spontaneous IgE biosynthesis.
Romagnani S, Damiani G, Giudizi MG, Biagiotti R, Almerigogna F, Delprete GF, Maggi E, Bargellesi A, Ricci M.
Clin Exp Immunol. 1982 Jul; 49(1):176-84.
[Clin Exp Immunol. 1982]