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Nature. 1978 Oct 12;275(5680):501-5.

A two-step fibrinogen--fibrin transition in blood coagulation.

Abstract

The kinetics of the thrombin-catalysed release of fibrino-peptides A and B from human fibrinogen have been investigated and a mechanism correlating the release of fibrinopeptides to fibrin formation is presented. The sequential release of fibrinopeptides results in sequential activation of two sets of polymerisation sites.

PMID:
692730
[PubMed - indexed for MEDLINE]
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