Horm Metab Res. 1982 May;14(5):271-4.

Serum 1,25-dihydroxyvitamin D in normal subjects and in patients with postmenopausal osteopenia. Influence of age, renal function and oestrogen therapy.

Abstract

The serum concentrations of 1,25-dihydroxyvitamin D (1,25-(OH)2D) were measured in 194 healthy subjects aged 15-90 years. The mean level was 32.8 +/- 12.5 pg/ml (SD) without age-dependent changes. The mean serum concentration was reduced (26.9 +/- 13.6 pg/ml) in 55 patients with postmenopausal osteopenia compared to 62 non-osteopenic age-matched controls (32.8 +/- 11.6 pg/ml) (p less than 0.02). The serum concentrations correlated positively with the creatinine clearances in 23 osteopenic patients studied. Treatment with oestradiol increased serum 1,25-(OH)2D significantly in postmenopausal women. A reduced production of 1,25-(OH)2D or a reduced sensitivity to this hormone may play a significant role in the pathogenesis of postmenopausal osteopenia.

PMID:: 6896507; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Research Support, Non-U.S. Gov't

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging. [J Clin Endocrinol Metab. 1982]
Acute effects of parathyroid hormone on vitamin D metabolism in patients with the bone loss of aging.
Sørensen OH, Lumholtz B, Lund B, Lund B, Hjelmstrand IL, Mosekilde L, Melsen F, Bishop JE, Norman AW. J Clin Endocrinol Metab. 1982 Jun; 54(6):1258-61.
[Relationship between serum 1,25-dihydroxyvitamin D and bone loss in postmenopausal women]. [Zhonghua Yi Xue Za Zhi. 2001]
[Relationship between serum 1,25-dihydroxyvitamin D and bone loss in postmenopausal women].
Zhu G, Wang H, Xu P. Zhonghua Yi Xue Za Zhi. 2001 Dec 10; 81(23):1443-6.
Normal serum concentrations of 1,25 dihydroxyvitamin D in osteoporosis. [Clin Rheumatol. 1990]
Normal serum concentrations of 1,25 dihydroxyvitamin D in osteoporosis.
Cantatore FP, Carrozzo M. Clin Rheumatol. 1990 Jun; 9(2):210-3.
Long term 25-hydroxyvitamin D3 therapy in postmenopausal osteoporosis: demonstration of responsive and nonresponsive subgroups. [J Clin Endocrinol Metab. 1983]
Long term 25-hydroxyvitamin D3 therapy in postmenopausal osteoporosis: demonstration of responsive and nonresponsive subgroups.
Zerwekh JE, Sakhaee K, Glass K, Pak CY. J Clin Endocrinol Metab. 1983 Feb; 56(2):410-3.
Review [Review of the concept of vitamin D "sufficiency and insufficiency"]. [Nefrologia. 2003]
Review [Review of the concept of vitamin D "sufficiency and insufficiency"].
Gómez Alonso C, Naves Díaz M, Rodríguez García M, Fernández Martín JL, Cannata Andía JB. Nefrologia. 2003; 23 Suppl 2:73-7.

See reviews... See all...

Cited by 3 PubMed Central articles

Review Calcium metabolism and vitamin D in the extreme longevity. [Exp Gerontol. 2008]
Review Calcium metabolism and vitamin D in the extreme longevity.
Passeri G, Vescovini R, Sansoni P, Galli C, Franceschi C, Passeri M, Italian Multicentric Study on Centenarians (IMUSCE). Exp Gerontol. 2008 Feb; 43(2):79-87. Epub 2007 Jul 4.
Regulation of vitamin D and calcium metabolism after gastrectomy. [Gut. 1985]
Regulation of vitamin D and calcium metabolism after gastrectomy.
Nilas L, Christiansen C, Christiansen J. Gut. 1985 Mar; 26(3):252-7.
Review Risk factors for osteoporosis and associated fractures. [Public Health Rep. 1989]
Review Risk factors for osteoporosis and associated fractures.
Kelsey JL. Public Health Rep. 1989 Sep-Oct; 104 Suppl:14-20.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Serum 1,25-dihydroxyvitamin D in normal subjects and in patients with postmenopa...
Serum 1,25-dihydroxyvitamin D in normal subjects and in patients with postmenopausal osteopenia. Influence of age, renal function and oestrogen therapy.
Horm Metab Res. 1982 May ;14(5):271-4.

PubMed
Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY...
Neuropeptide Y--a novel brain peptide with structural similarities to peptide YY and pancreatic polypeptide.
Nature. 1982 Apr 15 ;296(5858):659-60.

PubMed
Activities of branched-chain 2-oxo acid dehydrogenase and its components in skin...
Activities of branched-chain 2-oxo acid dehydrogenase and its components in skin fibroblasts from normal and classical-maple-syrup-urine-disease subjects.
Biochem J. 1981 Oct 15 ;200(1):59-67.

PubMed
Retraction of the eyelids secondary to thyroid ophthalmopathy--its surgical corr...
Retraction of the eyelids secondary to thyroid ophthalmopathy--its surgical correction with sclera and the fate of the graft.
Trans Am Ophthalmol Soc. 1980 ;78:657-85.

PubMed
[Vasolastine: not only miserable...].
[Vasolastine: not only miserable...].
Ned Tijdschr Geneeskd. 1980 Dec 27 ;124(52):2228-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: