Myosin phosphorylation and the cross-bridge cycle in arterial smooth muscle

Science. 1981 Jan 30;211(4481):495-7. doi: 10.1126/science.6893872.

Abstract

Phosphorylation of the 20,000-dalton light chain of myosin is closely correlated with cross-bridge cycling in arterial smooth muscle. Evidence is presented that dephosphorylation can produce an attached, noncycling cross-bridge (latch-bridge) which is responsible for the high economy of force maintenance in this tissue.

MeSH terms

  • Actins / metabolism*
  • Animals
  • Calcium / physiology
  • Carotid Arteries / physiology*
  • Macromolecular Substances
  • Muscle Contraction*
  • Muscle, Smooth / physiology*
  • Myosins / metabolism*
  • Phosphorylation
  • Protein Kinases / metabolism
  • Swine

Substances

  • Actins
  • Macromolecular Substances
  • Protein Kinases
  • Myosins
  • Calcium