Clin Genet. 1978 Aug;14(2):73-76.

Cluster of cystic fibrosis cases in a limited area of Brittany (France).

Bois E, Feingold J, Demenais F, Runavot Y, Jehanne M, Toudic L.

Abstract

Cystic fibrosis in the northern sector of the French "département" of Finistère is 1:1787 live births. Within this sector a concentration of the disease was found in a small area. The minimal frequency in this area, from 1946 to 1972, was calculated as 1 per 377 live births, the gene frequency being 0.0515. Genealogic analysis, going back to the beginning of the 18th century, showed a relationship between 8 of the 10 families to which the patients belonged. The origin of the deleterious genes may be explained by a least five primary ancestral couples living in the 18th century. Random drift is the most probable explanation for the concentration of cystic fibrosis in this region.

PMID:: 688690; [PubMed - indexed for MEDLINE]

MeSH Terms

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cystic fibrosis in the Ohio Amish: gene frequency and founder effect. [Hum Genet. 1983]
Cystic fibrosis in the Ohio Amish: gene frequency and founder effect.
Klinger KW. Hum Genet. 1983; 65(2):94-8.
Spatial and temporal distribution of cystic fibrosis and of its mutations in Brittany, France: a retrospective study from 1960. [Hum Genet. 2002]
Spatial and temporal distribution of cystic fibrosis and of its mutations in Brittany, France: a retrospective study from 1960.
Scotet V, Gillet D, Duguépéroux I, Audrézet MP, Bellis G, Garnier B, Roussey M, Rault G, Parent P, De Braekeleer M, et al. Hum Genet. 2002 Sep; 111(3):247-54. Epub 2002 Aug 1.
[Incidence of cystic fibrosis in Brittany (author's transl)]. [Rev Epidemiol Sante Publique. ...]
[Incidence of cystic fibrosis in Brittany (author's transl)].
Demenais F, Feingold J, Bois E, Jehanne M, Toudic L, Hennequet A. Rev Epidemiol Sante Publique. 1979 Jul 19; 27(1):51-15.
Review Cystic fibrosis in Jews: frequency and mutation distribution. [Genet Test. 1997]
Review Cystic fibrosis in Jews: frequency and mutation distribution.
Kerem B, Chiba-Falek O, Kerem E. Genet Test. 1997; 1(1):35-9.
Review [Oculopharyngeal muscular dystrophy. A census of French families and genealogic study]. [Rev Neurol (Paris). 1990]
Review [Oculopharyngeal muscular dystrophy. A census of French families and genealogic study].
Brunet G, Tomé FM, Samson F, Robert JM, Fardeau M. Rev Neurol (Paris). 1990; 146(6-7):425-9.

See reviews... See all...

Cited by 2 PubMed Central articles

Prevalence and survival of patients with cystic fibrosis in Northern Ireland, 1961-1971. [Ulster Med J. 1983]
Prevalence and survival of patients with cystic fibrosis in Northern Ireland, 1961-1971.
Nevin GB, Nevin NC, Redmond AO. Ulster Med J. 1983; 52(2):153-6.
Genealogical analysis of cystic fibrosis families and chromosome 7q RFLP haplotypes in the Hutterite Brethren. [Am J Hum Genet. 1989]
Genealogical analysis of cystic fibrosis families and chromosome 7q RFLP haplotypes in the Hutterite Brethren.
Fujiwara TM, Morgan K, Schwartz RH, Doherty RA, Miller SR, Klinger K, Stanislovitis P, Stuart N, Watkins PC. Am J Hum Genet. 1989 Mar; 44(3):327-37.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Cluster of cystic fibrosis cases in a limited area of Brittany (France).
Cluster of cystic fibrosis cases in a limited area of Brittany (France).
Clin Genet. 1978 Aug ;14(2):73-76.

PubMed
A comparative study of the prevalence, outcome, and prediction of bacteremia in ...
A comparative study of the prevalence, outcome, and prediction of bacteremia in children.
J Pediatr. 1983 Sep ;103(3):352-8.

PubMed
Alcohol and the nervous system.
Alcohol and the nervous system.
Clin Endocrinol Metab. 1978 Jul ;7(2):385-404.

PubMed
Suppression of avian hepatic lipid metabolism by solvent extracts of garlic: imp...
Suppression of avian hepatic lipid metabolism by solvent extracts of garlic: impact on serum lipids.
J Nutr. 1983 Sep ;113(9):1746-55.

PubMed
Blood intermediary metabolite and insulin concentrations after an overnight fast...
Blood intermediary metabolite and insulin concentrations after an overnight fast: reference ranges for adults, and interrelations.
Clin Chem. 1978 Sep ;24(9):1568-72.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Cluster of cystic fibrosis cases in a limited area of Brittany (France).

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information