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Genetics. 1983 Jul;104(3):449-56.

Evidence for balancing selection at HLA.

Abstract

HLA data from the A and B loci for 22 populations were compared with the neutrality expectations from Ewens' sampling theory. In 25 of 44 cases, there was significantly less homozygosity than expected. Although a number of factors can affect homozygosity in this manner, upon close examination only symmetrical balancing selection appears to be consistent with these data.

PMID:
6884768
[PubMed - indexed for MEDLINE]
PMCID:
PMC1202087
Free PMC Article
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