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Multiclonal origin of polyps in Gardner syndrome.
Electrophoretic analysis of glucose-6-phosphate dehydrogenase was performed on polyp tissue from three black female patients with Gardner syndrome and who are heterozygous for the A and B forms of this enzyme. Polyp tissues from the three patients displayed the AB phenotype. This finding suggests a multiclonal origin of polyps in Gardner syndrome. Studies of tumors originating from such polyps may provide information about the sequence of cellular events leading to malignant transformation.
PMID: 6879192 [PubMed - indexed for MEDLINE]
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Cited by 5 PubMed Central articles
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ReviewPolyclonal tumors in the mammalian intestine: are interactions among multiple initiated clones necessary for tumor initiation, growth, and progression?
Halberg RB, Dove WF.
Cell Cycle. 2007 Jan 1; 6(1):44-51. Epub 2007 Jan 28.
[Cell Cycle. 2007]
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X-inactivation patch size in human female tissue confounds the assessment of tumor clonality.
Novelli M, Cossu A, Oukrif D, Quaglia A, Lakhani S, Poulsom R, Sasieni P, Carta P, Contini M, Pasca A, et al.
Proc Natl Acad Sci U S A. 2003 Mar 18; 100(6):3311-4. Epub 2003 Feb 27.
[Proc Natl Acad Sci U S A. 2003]
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Localized gene action controlling intestinal neoplasia in mice.
Gould KA, Dove WF.
Proc Natl Acad Sci U S A. 1997 May 27; 94(11):5848-53.
[Proc Natl Acad Sci U S A. 1997]
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