Neurobehav Toxicol Teratol. 1983 May-Jun;5(3):363-6.

In utero alcohol exposure: functional and structural brain damage.

Abstract

Pregnant rats were intubated with alcohol throughout gestation. Control animals received vehicle and were pair-fed. At birth, all offspring were surrogate-fostered to nontreated dams. At 11 weeks of age, alcohol-exposed animals did not perform as well in a two-way shock avoidance task. The brains of these animals also exhibited significant deficits in dendritic structure in the area of the hippocampus. These behavioral observations may be a counterpart to the learning deficits associated with fetal alcohol effects, e.g., fetal alcohol syndrome in humans and animals, and the neuroanatomical observations suggest a structural basis for these learning deficits.

PMID:: 6877477; [PubMed - indexed for MEDLINE]

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Research Support, Non-U.S. Gov't

MeSH Terms

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Ethanol

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ETHANOL - HSDB

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Cited by 1 PubMed Central article

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