Raphe neurons: firing rate correlates with size of...[Eur J Pharmacol. 1983]

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1: Eur J Pharmacol. 1983 Jun 3;90(2-3):275-8.Links

Raphe neurons: firing rate correlates with size of drug response.

Jacobs BL, Heym J, Rasmussen K.

Significant negative correlations were obtained between the spontaneous discharge rate during waking and the neural response to systemic injections of either 5-MeODMT or LSD for serotonergic neurons in the dorsal raphe nucleus, nucleus centralis superior, and nucleus raphe pallidus of unanesthetized and unrestrained cats. These data are discussed in terms of an hypothesis which accounts for both the rate of spontaneous activity of serotonergic neurons and the magnitude of their response to serotonin agonist drugs in terms of autoreceptor density on individual neurons.

PMID: 6873185 [PubMed - indexed for MEDLINE]

Medullary serotonergic neurons are insensitive to 5-MeoDMT and LSD. [Eur J Pharmacol. 1982]
Differential effects of hallucinogenic drugs on the activity of serotonin-containing neurons in the nucleus centralis superior and nucleus raphe pallidus in freely moving cats. [J Pharmacol Exp Ther. 1984]
Activity of serotonin-containing neurons in nucleus centralis superior of freely moving cats. [Exp Neurol. 1984]
Acute and chronic effects of LSD and 5-MeODMT on raphe-evoked dorsal root potentials in the cat. [Life Sci. 1984]
Responses of serotonergic and non-serotonergic neurons in the rat nucleus raphe magnus to systemic lysergic acid diethylamide. [Neurosci Res. 1986]
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Raphe neurons: firing rate correlates with size of drug response.

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