Nature. 1983 Jun 30;303(5920):767-70.

'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer.

Pike MC, Krailo MD, Henderson BE, Casagrande JT, Hoel DG.

Abstract

For most cancer sites there is a linear log-log relationship between incidence and age. This relationship does not hold for breast cancer, and certain 'key' breast cancer risk factors suggest that breast tissue does not 'age' in step with calendar time. A quantitative description of 'breast tissue age' is suggested which brings the age-incidence curve of breast cancer into line with the common log-log cancers and explains quantitatively the known key risk factors. The model also explains the 'anomalous' finding that although early first birth is protective, late first birth carries a higher risk than nulliparity. US breast cancer rates are some four to six times the rates in Japan--the model suggests that the key risk factors, when considered jointly with weight, can explain about 85% of the difference.

PMID:: 6866078; [PubMed - indexed for MEDLINE]

MeSH Terms

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Nurses' health study: log-incidence mathematical model of breast cancer incidence. [J Natl Cancer Inst. 1996]
Nurses' health study: log-incidence mathematical model of breast cancer incidence.
Rosner B, Colditz GA. J Natl Cancer Inst. 1996 Mar 20; 88(6):359-64.
Review Reproductive factors and breast cancer. [Epidemiol Rev. 1993]
Review Reproductive factors and breast cancer.
Kelsey JL, Gammon MD, John EM. Epidemiol Rev. 1993; 15(1):36-47.
[Female sex hormones increase the risk of breast cancer]. [Tidsskr Nor Laegeforen. 1998]
[Female sex hormones increase the risk of breast cancer].
Vatten L. Tidsskr Nor Laegeforen. 1998 Aug 20; 118(19):2969-74.
Relationship between age maximum height is attained, age at menarche, and age at first full-term birth and breast cancer risk. [Cancer Epidemiol Biomarkers Pr...]
Relationship between age maximum height is attained, age at menarche, and age at first full-term birth and breast cancer risk.
Li CI, Littman AJ, White E. Cancer Epidemiol Biomarkers Prev. 2007 Oct; 16(10):2144-9.
Review Lifetime reproductive and anthropometric risk factors for breast cancer in postmenopausal women. [Breast Dis. 2005]
Review Lifetime reproductive and anthropometric risk factors for breast cancer in postmenopausal women.
Velie EM, Nechuta S, Osuch JR. Breast Dis. 2005-2006; 24:17-35.

See reviews... See all...

Cited by 56 PubMed Central articles

A model for breast cancer risk based on stem-cell theory. [Curr Oncol. 2012]
A model for breast cancer risk based on stem-cell theory.
A Countercurrents Series, Narod SA. Curr Oncol. 2012 Feb; 19(1):9-11.
Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells. [PLoS One. 2011]
Estrogen-mediated upregulation of Noxa is associated with cell cycle progression in estrogen receptor-positive breast cancer cells.
Liu W, Swetzig WM, Medisetty R, Das GM. PLoS One. 2011; 6(12):e29466. Epub 2011 Dec 22.
A genome-wide linkage study of mammographic density, a risk factor for breast cancer. [Breast Cancer Res. 2011]
A genome-wide linkage study of mammographic density, a risk factor for breast cancer.
Greenwood CM, Paterson AD, Linton L, Andrulis IL, Apicella C, Dimitromanolakis A, Kriukov V, Martin LJ, Salleh A, Samiltchuk E, et al. Breast Cancer Res. 2011; 13(6):R132. Epub 2011 Dec 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast can...
'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer.
Nature. 1983 Jun 30 ;303(5920):767-70.

PubMed
Mucociliary transport.
Mucociliary transport.
Ann Otol Rhinol Laryngol. 1978 Jul-Aug ;87(4 Pt 1):474-83.

PubMed
The effect of assessments and examinations on the learning of medical students.
The effect of assessments and examinations on the learning of medical students.
Med Educ. 1983 May ;17(3):165-71.

PubMed
Rapid digital filtering.
Rapid digital filtering.
J Nucl Med. 1983 Jul ;24(7):625-8.

PubMed
Application of a commercial radioassay test kit to the determination of vitamin ...
Application of a commercial radioassay test kit to the determination of vitamin B 12 in food.
Analyst. 1978 Aug ;103(1229):865-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

'Hormonal' risk factors, 'breast tissue age' and the age-incidence of breast cancer.

Abstract

MeSH Terms

MeSH Terms

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 56 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information