Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Science. 1983 Jun 3;220(4601):1055-7.

DNA methylation decreases in aging but not in immortal cells.

Abstract

When normal diploid fibroblasts from mice, hamsters, and humans were grown in culture, the 5-methylcytosine content of their DNA's markedly decreased. The greatest rate of loss of 5-methylcytosine residues was observed in mouse cells, which survived the least number of division. Immortal mouse cell lines had more stable rates of methylation.

PMID:
6844925
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk