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Diabetes. 1983 Apr;32(4):326-30.

Spontaneous diabetes mellitus in the BB/W rat. Effects of glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes.

Abstract

Combination immunosuppression therapy with long-acting glucocorticoids, cyclosporin-A, and antiserum to rat lymphocytes (ALS) reduced the severity of spontaneous diabetes among BioBreeding/Worcester rats and decreased the frequency of diabetes in susceptible littermates. Combination therapy with glucocorticoids and three injections of ALS reversed hyperglycemia in a significant number of acutely diabetic animals. These results strengthen the hypothesis that autoimmunity plays a role in the pathogenesis of diabetes in these animals and increase our understanding of the requirements of treatment protocols for the prevention and cure of this spontaneous syndrome.

PMID:
6832488
[PubMed - indexed for MEDLINE]
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