Lancet. 1977 May 28;1(8022):1133-5.

Haemorrhagic complications of heparin therapy.

Mant MJ, O'Brien BD, Thong KL, Hammond GW, Birtwhistle RV, Grace MG.

Abstract

In a prospective trial 76 patients with venous thromboembolism have received intermittent constant-dosage heparin or continuously infused heparin with laboratory control. Frequencies of bleeding were similar in both groups. 32% of all patients bled, 13% severely. Retroperitoneal haemorrhage occurred in 5 patients. Major spontaneous bleeding was commoner in older patients and minor spontaneous bleeding in women. Bleeding was uncommon during the first 2 days of treatment, and its daily frequency was relatively constant thereafter. 21% of surgical wounds and 7% of arterial and venous puncture sites bled. These preliminary results illustrate the hazards of heparin therapy and suggest that bleeding complications are more closely related to duration of therapy, age, sex, and surgical trauma than to method of administration.

PMID:: 68228; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Blood Thinners - MedlinePlus Health Information

Molecular Biology Databases

HEPARIN - HSDB

Supplemental Content

Save items

Related citations in PubMed

Management of heparin therapy: Controlled prospective trial. [N Engl J Med. 1975]
Management of heparin therapy: Controlled prospective trial.
Salzman EW, Deykin D, Shapiro RM, Rosenberg R. N Engl J Med. 1975 May 15; 292(20):1046-50.
Randomized prospective trial of continuous vs intermittent heparin therapy. [JAMA. 1976]
Randomized prospective trial of continuous vs intermittent heparin therapy.
Glazier RL, Crowell EB. JAMA. 1976 Sep 20; 236(12):1365-7.
Platelet count and the risk of bleeding in hospitalized patients with venous thromboembolism starting anticoagulant therapy. [Haemostasis. 1997]
Platelet count and the risk of bleeding in hospitalized patients with venous thromboembolism starting anticoagulant therapy.
Monreal M, Urrutia A, Marti S, Cuxart A, Roncales J. Haemostasis. 1997 Mar-Apr; 27(2):91-8.
Review Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism. [Cochrane Database Syst Rev. 2000]
Review Fixed dose subcutaneous low molecular weight heparins versus adjusted dose unfractionated heparin for venous thromboembolism.
van Den Belt AG, Prins MH, Lensing AW, Castro AA, Clark OA, Atallah AN, Burihan E. Cochrane Database Syst Rev. 2000; (2):CD001100.
Review Prophylaxis and therapy of venous thromboembolism. [CRC Crit Rev Clin Lab Sci. 1979]
Review Prophylaxis and therapy of venous thromboembolism.
Turpie AG, Hirsh J. CRC Crit Rev Clin Lab Sci. 1979; 10(3):247-74.

See reviews... See all...

Cited by 10 PubMed Central articles

Gigantic retroperitoneal hematoma as a complication of anticoagulation therapy with heparin in therapeutic doses: a case report. [J Med Case Rep. 2008]
Gigantic retroperitoneal hematoma as a complication of anticoagulation therapy with heparin in therapeutic doses: a case report.
Daliakopoulos SI, Bairaktaris A, Papadimitriou D, Pappas P. J Med Case Rep. 2008 May 17; 2:162. Epub 2008 May 17.
Isolation and characterization of a heparin with low antithrombin activity from the body of Styela plicata (Chordata-Tunicata). Distinct effects on venous and arterial models of thrombosis. [Thromb Res. 2007]
Isolation and characterization of a heparin with low antithrombin activity from the body of Styela plicata (Chordata-Tunicata). Distinct effects on venous and arterial models of thrombosis.
Santos JC, Mesquita JM, Belmiro CL, da Silveira CB, Viskov C, Mourier PA, Pavão MS. Thromb Res. 2007; 121(2):213-23. Epub 2007 May 4.
The effects of heparin treatment on hypertension and vascular lesions in stroke-prone spontaneously hypertensive rats. [Am J Pathol. 1981]
The effects of heparin treatment on hypertension and vascular lesions in stroke-prone spontaneously hypertensive rats.
Wilson SK, Solez K, Boitnott JK, Heptinstall RH. Am J Pathol. 1981 Jan; 102(1):62-71.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Haemorrhagic complications of heparin therapy.
Haemorrhagic complications of heparin therapy.
Lancet. 1977 May 28 ;1(8022):1133-5.

PubMed
Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a mono...
Diagnosis of Bernard-Soulier syndrome and Glanzmann's thrombasthenia with a monoclonal assay on whole blood.
J Clin Invest. 1983 Feb ;71(2):385-9.

PubMed
Cortisol secretion is inhibited during sleep in normal man.
Cortisol secretion is inhibited during sleep in normal man.
J Clin Endocrinol Metab. 1983 Feb ;56(2):352-8.

PubMed
Oxidation of hydrogen and reduction of methanol to methane is the sole energy so...
Oxidation of hydrogen and reduction of methanol to methane is the sole energy source for a methanogen isolated from human feces.
J Bacteriol. 1983 Feb ;153(2):1051-5.

PubMed
Urine composition following jejunoileal bypass.
Urine composition following jejunoileal bypass.
Eur Urol. 1983 ;9(1):35-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Haemorrhagic complications of heparin therapy.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 10 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information