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Antimicrob Agents Chemother. 1981 Feb;19(2):349-51.

Mode of action of Myxococcus xanthus antibiotic TA.

Abstract

Antibiotic TA inhibited incorporation of diaminopimelic acid and uridine diphosphate-N-acetylglucosamine into Escherichia coli cell walls without altering the ratio of cross-linked to uncross-linked peptidoglycan. Formation of the lipid intermediate was not blocked by TA, suggesting that TA interferes with polymerization of the lipid-disaccharide-pentapeptide.

PMID:
6812494
[PubMed - indexed for MEDLINE]
PMCID:
PMC181427
Free PMC Article
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