Proc Natl Acad Sci U S A. 1982 Jul;79(13):4153-5.

Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.

Faustman D, Hauptfeld V, Lacy P, Davie J.

Abstract

Streptozotocin-induced diabetes in mice can be reversed by transplantation of islets of Langerhans from histoincompatible mice if the islets are treated with anti-Ia-serum and complement before transplantation. Here we show that anti-Ia-treated islets most likely induce tolerance in the recipient animals. Daily injections of recipient-specific anti-I-J-serum (beginning 80 or more days after transplantation) and small numbers of donor splenocytes caused the prompt rejection of the islets in half of the animals; neither anti-I-J-serum nor donor splenocytes alone were effective. It is likely that rejection of established allografts after this treatment is the result of abolition of the activity of allograft-specific suppressor cells.

PMID:: 6810361; [PubMed - indexed for MEDLINE]
PMCID:: PMC346595

Free PMC Article

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Blood Glucose

Grant Support

LinkOut - more resources

Full Text Sources

Medical

Islet Cell Transplantation - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Intrathymic inoculation of donor antigen: an ineffective strategy for prolonging xenograft survival. [Xenotransplantation. 1999]
Intrathymic inoculation of donor antigen: an ineffective strategy for prolonging xenograft survival.
Tran HM, Patel A, Allen RD, O'Connell PJ. Xenotransplantation. 1999 May; 6(2):147-54.
Locally expressed CTLA4-Ig in a pancreatic beta-cell line suppresses accelerated graft rejection response induced by donor-specific transfusion. [Diabetologia. 2002]
Locally expressed CTLA4-Ig in a pancreatic beta-cell line suppresses accelerated graft rejection response induced by donor-specific transfusion.
Kimura F, Gotoh M, Tanaka T, Luo Z, Miyazaki J, Uede T, Monden M, Miyasaka M. Diabetologia. 2002 Jun; 45(6):831-40. Epub 2002 May 25.
Differences in susceptibility to rejection of mouse pancreatic islet allografts disparate for class I or class II major histocompatibility antigens. [J Surg Res. 1983]
Differences in susceptibility to rejection of mouse pancreatic islet allografts disparate for class I or class II major histocompatibility antigens.
Morrow CE, Sutherland DE, Steffes MW, Kaufman D, Najarian JS, Bach FH. J Surg Res. 1983 Apr; 34(4):358-66.
Review The reversal of diabetes by pancreatic islet transplantation. [Diabetes. 1982]
Review The reversal of diabetes by pancreatic islet transplantation.
Prowse SJ, Lafferty KJ, Simeonovic CJ, Agostino M, Bowen KM, Steele EJ. Diabetes. 1982 Aug; 31 Suppl 4:30-8.
Review Islet transplantation in treating diabetes. [Annu Rev Med. 1986]
Review Islet transplantation in treating diabetes.
Lacy PE, Scharp DW. Annu Rev Med. 1986; 37:33-40.

See reviews... See all...

Cited by 1 PubMed Central article

Pancreatic islet transplantation--experimental experience and clinical potential. [West J Med. 1985]
Pancreatic islet transplantation--experimental experience and clinical potential.
Lafferty KJ. West J Med. 1985 Dec; 143(6):853-7.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Demonstration of active tolerance in maintenance of established islet of Langerh...
Demonstration of active tolerance in maintenance of established islet of Langerhans allografts.
Proc Natl Acad Sci U S A. 1982 Jul ;79(13):4153-5.

PubMed
Suggested amnesia and order of recall as a function of hypnotic susceptibility a...
Suggested amnesia and order of recall as a function of hypnotic susceptibility and learning conditions in chronic schizophrenic patients.
Int J Clin Exp Hypn. 1978 Oct ;26(4):268-80.

PubMed
Interactions between folates and carbamazepine or valproate in the rat.
Interactions between folates and carbamazepine or valproate in the rat.
Neurology. 1982 Sep ;32(9):965-9.

PubMed
Removal of lower third molar germs by lateral trepanation and conventional techn...
Removal of lower third molar germs by lateral trepanation and conventional technique. A comparative study.
Int J Oral Surg. 1981 Aug ;10(4):251-4.

PubMed
The P300 component of the event-related brain potential as an index of informati...
The P300 component of the event-related brain potential as an index of information processing.
Biol Psychol. 1982 Feb-Mar ;14(1-2):1-52.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: