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1: Arch Ophthalmol. 1982 May;100(5):785-7.Click here to read Links

Protein deficiency and treatment of xerophthalmia.

Sommer A, Tarwotjo I.

In a controlled clinical trial of massive-dose vitamin A therapy for xerophthalmia, holo-retinol-binding protein (holo-RBP) response was related to baseline protein status. Corneal healing was more commonly delayed or transient in children with protein-energy malnutrition (PEM), despite the vast majority achieving holo-RBP levels incompatible with severe corneal destruction. Correction of PEM is essential to ensuring a sustained clinical cure, and repeated massive vitamin A therapy is advisable until that occurs.

PMID: 6805451 [PubMed - indexed for MEDLINE]