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Br J Clin Pharmacol. 1981 Dec;12(6):819-24.

Sodium valproate and cognitive functioning in normal volunteers.


1 The effects of sodium valproate on the performance of a series of psychological tests and mood was studied. 2 Ten healthy male volunteers received sodium valproate and placebo, each for a period of 2 weeks, in a double-blind cross-over design. Dosage of sodium valproate was increased to 800 mg/day in the first week and to 1 g/day in the second week of treatment. 3 Psychological testing took place on three occasions, before and on completion of each of the two treatment periods. 4 The few significant differences between drug and placebo conditions indicated impairment on sodium valproate. 5 The findings are discussed in relation to those from a similarly designed study of the anticonvulsant phenytoin. Implications for epilepsy are also considered.

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