Science. 1981 Dec 11;214(4526):1239-41.

Type III hyperlipoproteinemia associated with apolipoprotein E deficiency.

Ghiselli G, Schaefer EJ, Gascon P, Breser HB Jr.

Abstract

Subjects with type III hyperlipoproteinemia develop premature atherosclerosis and have hyperlipidemia due to an increase in cholesterol-rich very low density lipoproteins (VLDL) of abnormal electrophoretic mobility. Apolipoprotein E is a major protein constituent of VLDL and appears to be important for the hepatic uptake of triglyceride-rich lipoproteins. A new kindred of patients with type III hyperlipoproteinemia is described in which no plasma apolipoprotein E could be detected, consistent with the concept that type III hyperlipoproteinemia may be due to an absence or striking deficiency of apolipoprotein E.

PMID:: 6795720; [PubMed - indexed for MEDLINE]

MeSH Terms, Substances

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Supplemental Content

Save items

Related citations in PubMed

Distribution of apolipoprotein E isoforms between very low and high density lipoproteins of normal subjects and hyperlipidemic patients with special reference to type III hyperlipidemia. [Acta Med Scand. 1984]
Distribution of apolipoprotein E isoforms between very low and high density lipoproteins of normal subjects and hyperlipidemic patients with special reference to type III hyperlipidemia.
Holmquist L. Acta Med Scand. 1984; 215(2):113-20.
Apolipoprotein EBethesda: a new variant of apolipoprotein E associated with type III hyperlipoproteinemia. [J Clin Endocrinol Metab. 1983]
Apolipoprotein EBethesda: a new variant of apolipoprotein E associated with type III hyperlipoproteinemia.
Gregg RE, Ghiselli G, Brewer HB Jr. J Clin Endocrinol Metab. 1983 Nov; 57(5):969-74.
Genetic transmission of isoapolipoprotein E phenotypes in a large kindred: relationship to dysbetalipoproteinemia and hyperlipidemia. [Metabolism. 1981]
Genetic transmission of isoapolipoprotein E phenotypes in a large kindred: relationship to dysbetalipoproteinemia and hyperlipidemia.
Hazzard WR, Warnick GR, Utermann G, Albers JJ. Metabolism. 1981 Jan; 30(1):79-88.
Review Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia. [Ann N Y Acad Sci. 1985]
Review Lipoproteins of special significance in atherosclerosis. Insights provided by studies of type III hyperlipoproteinemia.
Mahley RW, Innerarity TL, Rall SC Jr, Weisgraber KH. Ann N Y Acad Sci. 1985; 454:209-21.
Review Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III). [Ric Clin Lab. 1982]
Review Apolipoprotein E (role in lipoprotein metabolism and pathophysiology of hyperlipoproteinemia type III).
Utermann G. Ric Clin Lab. 1982 Jan-Mar; 12(1):23-30.

See reviews... See all...

Cited by 27 PubMed Central articles

Proteomic identification of biomarkers of vascular injury. [Am J Transl Res. 2011]
Proteomic identification of biomarkers of vascular injury.
Huang NF, Kurpinski K, Fang Q, Lee RJ, Li S. Am J Transl Res. 2011 Feb; 3(2):139-48. Epub 2010 Nov 21.
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions. [J Biol Chem. 2011]
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions.
Trusca VG, Fuior EV, Florea IC, Kardassis D, Simionescu M, Gafencu AV. J Biol Chem. 2011 Apr 22; 286(16):13891-904. Epub 2011 Mar 3.
Review The fat-fed apolipoprotein E knockout mouse brachiocephalic artery in the study of atherosclerotic plaque rupture. [J Biomed Biotechnol. 2011]
Review The fat-fed apolipoprotein E knockout mouse brachiocephalic artery in the study of atherosclerotic plaque rupture.
Bond AR, Jackson CL. J Biomed Biotechnol. 2011; 2011:379069. Epub 2010 Nov 7.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Type III hyperlipoproteinemia associated with apolipoprotein E deficiency.
Type III hyperlipoproteinemia associated with apolipoprotein E deficiency.
Science. 1981 Dec 11 ;214(4526):1239-41.

PubMed
Base of the neck extracapsular osteotomy for correction of deformity in slipped ...
Base of the neck extracapsular osteotomy for correction of deformity in slipped capital femoral epiphysis.
Clin Orthop Relat Res. 1978 May ;(132):98-101.

PubMed
Pituitary hormone response to head injury.
Pituitary hormone response to head injury.
Neurosurgery. 1981 Sep ;9(3):229-35.

PubMed
Autologous transfusion and total hip arthroplasty.
Autologous transfusion and total hip arthroplasty.
Clin Orthop Relat Res. 1978 May ;(132):39-45.

PubMed
Assessment and management of anorexia nervosa.
Assessment and management of anorexia nervosa.
MCN Am J Matern Child Nurs. 1981 Nov-Dec ;6(6):412-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: