Psychopharmacology (Berl). 1981;74(1):23-8.

Self-stimulation and amphetamine: tolerance to d and l isomers and cross tolerance to cocaine and methylphenidate.

Abstract

The effects of the d and l isomers of amphetamine on self-stimulation responding were tested following acute and chronic administration. Tolerance and post-drug depression of responding occurred in tests with both isomers, indicating no role for p-hydroxynorephedrine (PHN) which is one of the metabolites of d-amphetamine. In the second experiment, d-amphetamine, methylphenidate and cocaine all produced quantitatively and qualitatively similar effects on self-stimulation responding following acute administration. Following chronic administration of d-amphetamine, animals showed tolerance to all three drugs, indicating cross-tolerance among them. These data are consistent with an hypothesis that tolerance and post-drug depression following chronic amphetamine treatment are the result of decreases in postsynaptic receptor sensitivity, which would lead to a decreased effectiveness of all three drugs, regardless of their pre-synaptic mechanisms.

PMID:: 6791199; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Molecular Biology Databases

Supplemental Content

Related citations

The existence of tolerance to and cross-tolerance between d-amphetamine and methylphenidate for their effects on milk consumption and on differential-reinforcement-of-low-rate performance in the rat. [J Pharmacol Exp Ther. 1976]
The existence of tolerance to and cross-tolerance between d-amphetamine and methylphenidate for their effects on milk consumption and on differential-reinforcement-of-low-rate performance in the rat.
Pearl RG, Seiden LS. J Pharmacol Exp Ther. 1976 Sep; 198(3):635-47.
Chronic d-amphetamine or methamphetamine produces cross-tolerance to the discriminative and reinforcing stimulus effects of cocaine. [J Pharmacol Exp Ther. 1996]
Chronic d-amphetamine or methamphetamine produces cross-tolerance to the discriminative and reinforcing stimulus effects of cocaine.
Peltier RL, Li DH, Lytle D, Taylor CM, Emmett-Oglesby MW. J Pharmacol Exp Ther. 1996 Apr; 277(1):212-8.
Does tolerance develop to low doses of d- and l-amphetamine on locomotor activity in rats? [Pharmacol Biochem Behav. 1976]
Does tolerance develop to low doses of d- and l-amphetamine on locomotor activity in rats?
Weston PF, Overstreet DH. Pharmacol Biochem Behav. 1976 Dec; 5(6):645-9.
Review Methylphenidate and cocaine: the same effects on gene regulation? [Trends Pharmacol Sci. 2007]
Review Methylphenidate and cocaine: the same effects on gene regulation?
Yano M, Steiner H. Trends Pharmacol Sci. 2007 Nov; 28(11):588-96. Epub 2007 Oct 25.
Review Role of oxytocin in the neuroadaptation to drugs of abuse. [Psychoneuroendocrinology. 1994]
Review Role of oxytocin in the neuroadaptation to drugs of abuse.
Sarnyai Z, Kovács GL. Psychoneuroendocrinology. 1994; 19(1):85-117.

See reviews... See all...

Cited by 1 PubMed Central article

Review Neurologic aspects of cocaine abuse. [West J Med. 1988]
Review Neurologic aspects of cocaine abuse.
Rowbotham MC. West J Med. 1988 Oct; 149(4):442-8.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Self-stimulation and amphetamine: tolerance to d and l isomers and cross toleran...
Self-stimulation and amphetamine: tolerance to d and l isomers and cross tolerance to cocaine and methylphenidate.
Psychopharmacology (Berl). 1981 ;74(1):23-8.

PubMed
Expression of the B subunit of Escherichia coli heat-labile enterotoxin in a mar...
Expression of the B subunit of Escherichia coli heat-labile enterotoxin in a marine Vibrio and in a mutant that is pleiotropically defective in the secretion of extracellular proteins.
J Gen Microbiol. 1992 Apr ;138(4):719-24.

PubMed
Effect of extreme temperatures on drugs for prehospital ACLS.
Effect of extreme temperatures on drugs for prehospital ACLS.
Am J Emerg Med. 1993 Sep ;11(5):450-2.

PubMed
Early diagnosis and treatment of hinge abduction in Legg-Perthes disease.
Early diagnosis and treatment of hinge abduction in Legg-Perthes disease.
J Pediatr Orthop. 1996 Jan-Feb ;16(1):3-9.

PubMed
[Peripheral sensory neuropathy produced by a megadose of vitamin B6].
[Peripheral sensory neuropathy produced by a megadose of vitamin B6].
J UOEH. 1985 Jun 1 ;7(2):201-5.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Display Settings:

Send to: