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Science. 1980 May 2;208(4443):505-8.

L-Ornithine decarboxylase:an essential role in early mammalian embryogenesis.

Abstract

The highly selective, enzyme-activated, irreversible inhibitor of L-ornithine decarboxylase, DL-alpha-difluoromethylornithine, suppresses the increase in uterine L-ornithine decarboxylase activity associated with early embryogenesis in the mouse and arrests embryonic development at that stage. Contragestational effects were confirmed in the rat and rabbit. An increase in L-ornithine decarboxylase activity that leads to a rapid increase in putrescine concentration appears to be essential during a critical period after implantation for continued mammalian embryonal growth.

PMID:
6768132
[PubMed - indexed for MEDLINE]
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