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Human Protein Z.
Protein Z was purified from human plasma by a four-step procedure which included barium citrate adsorption, ammonium sulfate fractionation, DEAE-Sepharose chromatography, and blue agarose chromatography with a yield of 20%. It is a 62,000 mol wt protein with an extinction coefficient of 12.0. The concentration of Protein Z in pooled, citrated plasma is 2.2 micrograms/ml and its half-life in patients starting warfarin anticoagulation therapy is estimated to be less than 2.5 d. The NH2-terminal sequence is Ala-Gly-Ser-Tyr-Leu-Leu-(Gla)-(Gla)-Leu-Phe-(Gla)-Gly-Asn-Leu. Neither Protein Z nor its cleavage products, which were obtained by treatment of Protein Z with thrombin or plasmin, incorporated [3H]diisopropyl fluorophosphate. The physiological function of Protein Z remains unknown.
PMID: 6707212 [PubMed - indexed for MEDLINE]
PMCID: PMC425104
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Cited by 4 PubMed Central articles
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Protein Z-dependent protease inhibitor deficiency produces a more severe murine phenotype than protein Z deficiency.
Zhang J, Tu Y, Lu L, Lasky N, Broze GJ Jr.
Blood. 2008 May 15; 111(10):4973-8. Epub 2008 Mar 14.
[Blood. 2008]
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Plasma protein Z concentrations in pregnant women with idiopathic intrauterine bleeding and in women with spontaneous preterm labor.
Kusanovic JP, Espinoza J, Romero R, Hoppensteadt D, Nien JK, Kim CJ, Erez O, Soto E, Fareed J, Edwin S, et al.
J Matern Fetal Neonatal Med. 2007 Jun; 20(6):453-63.
[J Matern Fetal Neonatal Med. 2007]
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Prothrombotic phenotype of protein Z deficiency.
Yin ZF, Huang ZF, Cui J, Fiehler R, Lasky N, Ginsburg D, Broze GJ Jr.
Proc Natl Acad Sci U S A. 2000 Jun 6; 97(12):6734-8.
[Proc Natl Acad Sci U S A. 2000]
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Patient Drug Information
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Barium Sulfate (Baro-cat® , Baricon® , Barobag® , ...)
Barium sulfate is used to help doctors examine the esophagus (tube that connects the mouth and stomach), stomach, and intestine using x-rays or computed tomography (CAT scan, CT scan; a type of body scan that uses a comp...
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Warfarin (Coumadin® )
Warfarin is used to prevent blood clots from forming or growing larger in your blood and blood vessels. It is prescribed for people with certain types of irregular heartbeat, people with prosthetic (replacement or mechan...