J Chromatogr. 1978 Jul 1;146(1):33-41.

Determination of kynurenine by a simple gas-liquid chromatographic method applicable to urine, plasma, brain and cerebrospinal fluid.

Abstract

A simple, sensitive and specific method for the determination of kynurenine is described. This is based on alkaline cleavage of kynurenine, followed by solvent extraction, trifluoroacetylation and gas--liquid chromatography with electron capture detection. Using this method kynurenine has been determined in urine and plasma, and for the first time in brain and cerebrospinal fluid. Increases in kynurenine in brain, plasma and urine are demonstrated following tryptophan administration to man and rat.

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Cited by 2 PubMed Central articles

Proceeding of the British Pharmacological Society, Clinical Pharmacology Section, 16-18th December, 1980, University of London. Abstracts. [Br J Clin Pharmacol. 1981]
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Determination of kynurenine by a simple gas-liquid chromatographic method applic...
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Determination of kynurenine by a simple gas-liquid chromatographic method applicable to urine, plasma, brain and cerebrospinal fluid.

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Cited by 2 PubMed Central articles

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