Helv Paediatr Acta. 1978 Apr;33(1):11-6.

Intelligence of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, their parents and unaffected siblings.

Wenzel U, Schneider M, Zachmann M, Knorr-Mürset G, Weber A, Prader A.

Abstract

IQ measurements were performed in 33 patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (110.6 +/- 13.9), in 29 unaffected siblings (113.8 +/- 11.3) and in 48 parents (104.4 +/- 9.4). The results were significantly higher than normal in the patients and siblings, but not in the parents. They were also significantly higher in the patients and siblings as compared to the parents. It is concluded that neither pre- or postnatal androgen exposure nor a genetic linkage can be made responsible for the increased IQ in congenital adrenal hyperplasia, but that more likely methodological factors (such as outdated standards) account for the higher values in patients and siblings.

PMID:: 669967; [PubMed - indexed for MEDLINE]

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Close genetic linkage between HLA and congenital adrenal hyperplasia (21-hydroxylase deficiency). [Lancet. 1977]
Close genetic linkage between HLA and congenital adrenal hyperplasia (21-hydroxylase deficiency).
Dupont B, Oberfield SE, Smithwick EM, Lee TD, Levine LS. Lancet. 1977 Dec 24-31; 2(8052-8053):1309-12.
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Genetic mapping of the 21-hydroxylase-deficiency gene within the HLA linkage group.
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Handwerger S, Silverstein JH. Urol Clin North Am. 1977 Jun; 4(2):193-209.
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Intelligence of patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency, their parents and unaffected siblings.

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