-
Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone.
Nucleotide sequence comparisons of the single gene for the human luteinizing hormone gene beta subunit with two of the seven genes for the human chorionic gonadotropin beta subunit suggest that the beta human chorionic gonadotropin genes have evolved from an ancestral beta luteinizing hormone gene by a series of selected changes with very little neutral drift. Moreover, the 24 amino acid carboxy-terminal extension of the human chorionic gonadotropin beta subunit appears to have arisen by a single base deletion that incorporated the 3'-untranslated region of the ancestral beta luteinizing hormone gene into the coding region.
PMID: 6690982 [PubMed - indexed for MEDLINE]
-
Cited by 26 PubMed Central articles
-
A carboxyl-terminal sequence in the lutropin beta subunit contributes to the sorting of lutropin to the regulated pathway.
Jablonka-Shariff A, Pearl CA, Comstock A, Boime I.
J Biol Chem. 2008 Apr 25; 283(17):11485-92. Epub 2008 Feb 21.
[J Biol Chem. 2008]
-
Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues.
Rull K, Hallast P, Uusküla L, Jackson J, Punab M, Salumets A, Campbell RK, Laan M.
Mol Hum Reprod. 2008 Jan; 14(1):23-31. Epub 2007 Nov 29.
[Mol Hum Reprod. 2008]
-
The evolution and genomic landscape of CGB1 and CGB2 genes.
Hallast P, Rull K, Laan M.
Mol Cell Endocrinol. 2007 Jan 2; 260-262:2-11. Epub 2006 Oct 19.
[Mol Cell Endocrinol. 2007]
- » See all...