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Toxicol Lett. 1983 Jan;15(1):7-12.

Demonstration of vitamin D-binding protein (Gc-globulin) in the urine of Itai-itai disease patients.


Vitamin D-binding protein (VDBP, known as Gc-globulin) was discovered by an immunochemical method in the urine of patients with Itai-itai disease. The urine and sera of Itai-itai disease patients produced specific precipitin lines with anti-human VDBP antisera. The electrophoretic mobility of the protein in the urine is the same as that in the serum. A significant correlation was found between VDBP and beta 2-microglobulin in the urine. Based on this result, it was concluded that Itai-itai disease is associated with disturbances of vitamin D transport and/or metabolism.

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