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Science. 1977 Apr 15;196(4287):317-9.

Niemann-Pick disease experimental model: sphingomyelinase reduction induced by AY-9944.

Abstract

Organs of rats treated with the drug A Y-9944 for 5 days showed a significant reduction in sphingomyelinase activity. Evidence is presented which suggests that the reduction is due to impaired enzyme synthesis.

PMID:
66749
[PubMed - indexed for MEDLINE]
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