Vision Res. 1983;23(12):1607-13.

The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cell discharge of rabbit retina.

Abstract

Perfusion of 100 microM 2-amino-4-phosphonobutyric acid (APB) into the in vivo rabbit eye-cup selectively and reversibly blocked the b-wave of the ERG and all On responses from retinal ganglion cells. In contrast, Off responses were occasionally enhanced, sometimes dramatically. The antagonistic surround inputs to Off ganglion cells, identified by their latency to light stimulation and magnesium sensitivity, were unchanged by APB. These observations suggest that APB selectively blocks depolarizing bipolar cells in rabbit retina in close agreement with the results of Slaughter and Miller (1981) from mudpuppy retina. We conclude that APB may be useful as a pharmacological tool to differentiate On and Off pathways in the rabbit visual system.

PMID:: 6666062; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Supplemental Content

Save items

Related citations in PubMed

Effect of ON pathway blockade on directional selectivity in the rabbit retina. [J Neurophysiol. 1995]
Effect of ON pathway blockade on directional selectivity in the rabbit retina.
Kittila CA, Massey SC. J Neurophysiol. 1995 Feb; 73(2):703-12.
A differential effect of APB on ON- and OFF-center ganglion cells in the dark adapted rabbit retina. [Brain Res. 1996]
A differential effect of APB on ON- and OFF-center ganglion cells in the dark adapted rabbit retina.
Jin XT, Brunken WJ. Brain Res. 1996 Feb 5; 708(1-2):191-6.
Bipolar origin of synaptic inputs to sustained OFF-ganglion cells in the mudpuppy retina. [J Neurophysiol. 1988]
Bipolar origin of synaptic inputs to sustained OFF-ganglion cells in the mudpuppy retina.
Arkin MS, Miller RF. J Neurophysiol. 1988 Sep; 60(3):1122-42.
Review Development of On and Off retinal pathways and retinogeniculate projections. [Prog Retin Eye Res. 2004]
Review Development of On and Off retinal pathways and retinogeniculate projections.
Chalupa LM, Günhan E. Prog Retin Eye Res. 2004 Jan; 23(1):31-51.
Review The rod bipolar cell of the mammalian retina. [Vis Neurosci. 1991]
Review The rod bipolar cell of the mammalian retina.
Wässle H, Yamashita M, Greferath U, Grünert U, Müller F. Vis Neurosci. 1991 Jul-Aug; 7(1-2):99-112.

See reviews... See all...

Cited by 10 PubMed Central articles

Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system. [PLoS One. 2012]
Novel expression patterns of metabotropic glutamate receptor 6 in the zebrafish nervous system.
Huang YY, Haug MF, Gesemann M, Neuhauss SC. PLoS One. 2012; 7(4):e35256. Epub 2012 Apr 16.
Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses. [Neuroscience. 2010]
Selective activation of mGluR8 receptors modulates retinal ganglion cell light responses.
Quraishi S, Reed BT, Duvoisin RM, Taylor WR. Neuroscience. 2010 Mar 31; 166(3):935-41. Epub 2010 Jan 20.
Different mechanisms generate maintained activity in ON and OFF retinal ganglion cells. [J Neurosci. 2007]
Different mechanisms generate maintained activity in ON and OFF retinal ganglion cells.
Margolis DJ, Detwiler PB. J Neurosci. 2007 May 30; 27(22):5994-6005.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.
Cited in Books
NCBI Bookshelf books that cite the current articles.

Recent activity

Clear Turn Off Turn On

The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cel...
The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cell discharge of rabbit retina.
Vision Res. 1983 ;23(12):1607-13.

PubMed
Facilitating patient compliance in glaucoma therapy.
Facilitating patient compliance in glaucoma therapy.
Surv Ophthalmol. 1983 Dec ;28 Suppl:252-8.

PubMed
Serum testosterone and sexual activity and interest in men.
Serum testosterone and sexual activity and interest in men.
Arch Sex Behav. 1978 Mar ;7(2):97-103.

PubMed
[Mucocele of the floor of the mouth (ranula): the result of interstitial salivar...
[Mucocele of the floor of the mouth (ranula): the result of interstitial salivary leakage].
S Afr Med J. 1983 Dec 24 ;64(27):1052-6.

PubMed
Identification of quinolinic acid in rat and human brain tissue.
Identification of quinolinic acid in rat and human brain tissue.
Neurosci Lett. 1983 Nov 11 ;41(3):247-52.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

The effects of 2-amino-4-phosphonobutyric acid (APB) on the ERG and ganglion cell discharge of rabbit retina.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 10 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information