Neurosci Lett. 1983 Nov 11;41(3):247-52.

Identification of quinolinic acid in rat and human brain tissue.

Wolfensberger M, Amsler U, Cuénod M, Foster AC, Whetsell WO Jr, Schwarcz R.

Abstract

An analytical technique for the determination of the excitotoxic compound quinolinic acid (2,3-pyridine dicarboxylic acid) in brain tissue has been developed. Following sample prepurification by ion exchange and high pressure liquid chromatography, quinolinic acid is converted to the dihexafluoroisopropyl ester and the derivative is analyzed by mass fragmentography. Using the present technique quinolinic acid has been identified in both rat and human brain tissue.

PMID:: 6664615; [PubMed - indexed for MEDLINE]

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Identification of quinolinic acid in rat and human brain tissue.

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Publication Types, MeSH Terms, Substances, Grant Support

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Cited by 7 PubMed Central articles

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