[Peculiarities of nuclear genome transcription in the early stages of liver regeneration. Complex nature of the activating effect of the cytoplasmic regenerating factor on transcription in isolated rat liver nuclei]

Biokhimiia. 1983 Nov;48(11):1774-7.
[Article in Russian]

Abstract

The cytosol fractions from resting rat liver and from the liver 1 hour after partial hepatectomy which were not adsorbed on DEAE-cellulose were subjected to gel filtration with a view of elucidating the mechanism of its activating effect on the RNA-synthesizing ability of isolated nuclei of resting liver. The activating effect of this fraction is a complex one and includes both specific and non-specific factors. A subfraction typical for regenerating liver was detected, which activates RNA elongation in a synthesizing system with isolated nuclei of resting liver.

Publication types

  • English Abstract

MeSH terms

  • Animals
  • Cell Nucleus / metabolism*
  • Cytosol / physiology
  • Genes*
  • Liver / metabolism*
  • Liver Regeneration*
  • Male
  • Rats
  • Transcription, Genetic*