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Helv Paediatr Acta. 1983 Oct;38(4):323-7.

CSF protein values in infants and children.


Total protein, albumin and gamma-globulin values were determined in CSF of 139 children. They had been referred to the emergency department of the Children's Hospital of the University of Berne during the last year because of suspected meningitis which, however, was not confirmed. In newborns and infants the normal range of protein values was wide, 0.1-0.65 g/l. It fell to minimal values at age 3-4 years, and increased gradually thereafter to adult levels which were reached at age 6-8 years. The observed changes during early childhood are mainly due to variations in the albumine fraction. The results are different from the ones reported by Ammon and Richterich [1] who claimed constantly falling protein levels during childhood up to adult values. Similar results in comparison to ours were obtained by other laboratories using the same method [6,7]. Our study therefore supports the usefulness of Bradford's [2] method for routine CSF work-up.

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