Acta Med Scand. 1978;203(5):437-43.

Transitory renal failure following rapid administration of a relatively large amount of hematin in a patient with acute intermittent porphyria in clinical remission.

Dhar GJ, Bossenmaier I, Cardinal R, Petryka ZJ, Watson CJ.

Abstract

Transitory renal failure occurred in a patient with acute intermittent porphyria in clinical remission following i.v. administration of 1 000 mg hematin. The clinical and biochemical picture suggested "acute tubular necrosis", which was followed by a prompt and complete return of renal function without any late sequelae. The renal failure is thought to have resulted from the presence of circulating free hematin, formed as a result of rapid administration of such a relatively large amount. Such a complication has not occurred in patients given hematin for acute porphyric relapse, in whom much smaller amounts have been infused.

PMID:: 665312; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

Case Reports

MeSH Terms

Substances

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

Effects of hematin in hepatic porphyria. Further studies. [Ann Intern Med. 1975]
Effects of hematin in hepatic porphyria. Further studies.
Dhar GJ, Bossenmaier I, Petryka ZJ, Cardinal R, Watson CJ. Ann Intern Med. 1975 Jul; 83(1):20-30.
Hematin treatment of acute porphyria. Early remission of an almost fatal relapse. [JAMA. 1976]
Hematin treatment of acute porphyria. Early remission of an almost fatal relapse.
Peterson A, Bossenmaier I, Cardinal R, Watson CJ. JAMA. 1976 Feb 2; 235(5):520-2.
[Hematin treatment of acute intermittent porphyria. A case report (author's transl)]. [Rev Bras Pesqui Med Biol. 1979]
[Hematin treatment of acute intermittent porphyria. A case report (author's transl)].
Marchiori PE, de Assis JL, Scaff M, Do Serro-Azul LG, Moraes EC, Bacheschi LA, Yassuda N. Rev Bras Pesqui Med Biol. 1979 Sep; 12(4-5):325-33.
Review Hematin therapy for the porphyric attack. [Semin Liver Dis. 1982]
Review Hematin therapy for the porphyric attack.
Pierach CA. Semin Liver Dis. 1982 May; 2(2):125-31.
Review [Hematin in the treatment of acute hepatic porphyrias]. [Internist (Berl). 1979]
Review [Hematin in the treatment of acute hepatic porphyrias].
Thier W. Internist (Berl). 1979 Sep; 20(9):454-5.

See reviews... See all...

Cited by 8 PubMed Central articles

Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse. [PLoS One. 2012]
Renal failure affects the enzymatic activities of the three first steps in hepatic heme biosynthesis in the acute intermittent porphyria mouse.
Unzu C, Sampedro A, Sardh E, Mauleón I, Enríquez de Salamanca R, Prieto J, Salido E, Harper P, Fontanellas A. PLoS One. 2012; 7(3):e32978. Epub 2012 Mar 6.
Carbon monoxide reverses diabetic gastroparesis in NOD mice. [Am J Physiol Gastrointest Live...]
Carbon monoxide reverses diabetic gastroparesis in NOD mice.
Kashyap PC, Choi KM, Dutta N, Linden DR, Szurszewski JH, Gibbons SJ, Farrugia G. Am J Physiol Gastrointest Liver Physiol. 2010 Jun; 298(6):G1013-9. Epub 2010 Apr 8.
The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo. [Am J Pathol. 2000]
The indispensability of heme oxygenase-1 in protecting against acute heme protein-induced toxicity in vivo.
Nath KA, Haggard JJ, Croatt AJ, Grande JP, Poss KD, Alam J. Am J Pathol. 2000 May; 156(5):1527-35.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Gene (OMIM)
Gene records associated with Online Mendelian Inheritance in Man (OMIM) records that cite the current articles in their reference lists.
Nucleotide (Weighted)
Nucleotide records associated with the current articles through the Gene database. These are the related sequences on the Gene record that are added manually by NCBI.
OMIM (calculated)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as references in the light bulb links within or in the citations at the end of the OMIM record. The references available through the light bulb link are collected using the PubMed related articles algorithm to identify records with similar terminology to the OMIM record.
OMIM (cited)
Online Mendelian Inheritance in Man (OMIM) records that include the current articles as reference cited at the end of the OMIM record.
Protein (Weighted)
Protein records associated with the current articles through related Gene database records. These are the related sequences on the Gene record that are added manually by NCBI.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Transitory renal failure following rapid administration of a relatively large am...
Transitory renal failure following rapid administration of a relatively large amount of hematin in a patient with acute intermittent porphyria in clinical remission.
Acta Med Scand. 1978 ;203(5):437-43.

PubMed
Depression spectrum disease or character spectrum disorder? A clinical study of ...
Depression spectrum disease or character spectrum disorder? A clinical study of major depressives with familial alcoholism or sociopathy.
Compr Psychiatry. 1983 Nov-Dec ;24(6):589-95.

PubMed
The dementia of dementia praecox.
The dementia of dementia praecox.
Acta Psychiatr Scand. 1978 Apr ;57(4):305-24.

PubMed
Herpes zoster: treatment with cimetidine.
Herpes zoster: treatment with cimetidine.
Can Med Assoc J. 1983 Dec 15 ;129(12):1284-5.

PubMed
Validation of the "CAGE" alcoholism screening test in a Brazilian psychiatric in...
Validation of the "CAGE" alcoholism screening test in a Brazilian psychiatric inpatient hospital setting.
Braz J Med Biol Res. 1983 Oct ;16(3):215-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: