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Am J Med Genet. 1983 Oct;16(2):169-72.

Segregation of chromosomes into the spermatozoa of a man heterozygous for a 14;21 Robertsonian translocation.


Twenty-four spermatozoa from a man heterozygous for a Robertsonian translocation (45,XY,-14,-21,+t(14q;21q) were studied cytogenetically in order to determine the meiotic segregation of the translocation. When compared to the expected 1:1 ratio we observed a greater number of chromosomally normal sperm than sperm with the balanced translocation. Three sperm carried the translocation in an unbalanced form.

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