Am J Clin Nutr. 1983 Dec;38(6):999-1005.

Energy expenditure from doubly labeled water: some fundamental considerations in humans.

Abstract

The isotopic loading dose and metabolic period for the measurement of energy expenditure in humans by the doubly labeled water method were predicted by a propagation of error analysis. Factors considered for sources of error were analytical errors in the mass spectrometric determination of isotopic enrichments, biological variation in the isotopic enrichments, uncertainties in total body water (TBW), evaporative water loss, and metabolic fuel. The predicted optimal isotopic loading doses were 0.3 g H2 18O/kg TBW and 0.12 g 2H2O/kg TBW for all subjects except neonates in which they were 0.4 g H2 18O/kg TBW and 0.16 g 2H2O/kg TBW. The optimal metabolic periods were 3 to 14 days in neonates and children, and 5 to 28 days in adults. The theoretical coefficient of variation of the doubly labeled water method for the measurement of energy expenditure is between 4 and 8%.

PMID:: 6650456; [PubMed - indexed for MEDLINE]

Free full text

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Oxygen Isotopes

Grant Support

LinkOut - more resources

Full Text Sources

Supplemental Content

Save items

Related citations in PubMed

Measurement of energy expenditure in humans by doubly labeled water method. [J Appl Physiol. 1982]
Measurement of energy expenditure in humans by doubly labeled water method.
Schoeller DA, van Santen E. J Appl Physiol. 1982 Oct; 53(4):955-9.
Review Analytic requirements for the doubly labeled water method. [Obes Res. 1995]
Review Analytic requirements for the doubly labeled water method.
Schoeller DA, Taylor PB, Shay K. Obes Res. 1995 Mar; 3 Suppl 1:15-20.
Five-day comparison of the doubly labeled water method with respiratory gas exchange. [Am J Clin Nutr. 1984]
Five-day comparison of the doubly labeled water method with respiratory gas exchange.
Schoeller DA, Webb P. Am J Clin Nutr. 1984 Jul; 40(1):153-8.
Field use of D2 18O to measure energy expenditure of soldiers at different energy intakes. [J Appl Physiol. 1989]
Field use of D2 18O to measure energy expenditure of soldiers at different energy intakes.
DeLany JP, Schoeller DA, Hoyt RW, Askew EW, Sharp MA. J Appl Physiol. 1989 Nov; 67(5):1922-9.
Review Use of the doubly labeled water method for measurement of energy expenditure, total body water, water intake, and metabolizable energy intake in humans and small animals. [Can J Physiol Pharmacol. 1989]
Review Use of the doubly labeled water method for measurement of energy expenditure, total body water, water intake, and metabolizable energy intake in humans and small animals.
Roberts SB. Can J Physiol Pharmacol. 1989 Oct; 67(10):1190-8.

See reviews... See all...

Cited by 7 PubMed Central articles

Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy. [J Gerontol A Biol Sci Med Sci....]
Design and conduct of the CALERIE study: comprehensive assessment of the long-term effects of reducing intake of energy.
Rochon J, Bales CW, Ravussin E, Redman LM, Holloszy JO, Racette SB, Roberts SB, Das SK, Romashkan S, Galan KM, et al. J Gerontol A Biol Sci Med Sci. 2011 Jan; 66(1):97-108. Epub 2010 Oct 5.
Validation of cross-sectional time series and multivariate adaptive regression splines models for the prediction of energy expenditure in children and adolescents using doubly labeled water. [J Nutr. 2010]
Validation of cross-sectional time series and multivariate adaptive regression splines models for the prediction of energy expenditure in children and adolescents using doubly labeled water.
Butte NF, Wong WW, Adolph AL, Puyau MR, Vohra FA, Zakeri IF. J Nutr. 2010 Aug; 140(8):1516-23. Epub 2010 Jun 23.
Estimating total body water content in suckling and lactating llamas (Lama glama) by isotope dilution. [Trop Anim Health Prod. 2010]
Estimating total body water content in suckling and lactating llamas (Lama glama) by isotope dilution.
Riek A, Gerken M. Trop Anim Health Prod. 2010 Aug; 42(6):1189-93. Epub 2010 Apr 10.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Energy expenditure from doubly labeled water: some fundamental considerations in...
Energy expenditure from doubly labeled water: some fundamental considerations in humans.
Am J Clin Nutr. 1983 Dec ;38(6):999-1005.

PubMed
[Ultrastructural pathology of the alveolar apparatus in experimental drowning].
[Ultrastructural pathology of the alveolar apparatus in experimental drowning].
Z Rechtsmed. 1983 ;91(1):47-60.

PubMed
Synaptic patterns and response properties of bipolar and ganglion cells in the c...
Synaptic patterns and response properties of bipolar and ganglion cells in the cat retina.
Vision Res. 1983 ;23(10):1183-95.

PubMed
The role of traditional medicine in ophthalmology in Kenya.
The role of traditional medicine in ophthalmology in Kenya.
Soc Sci Med. 1983 ;17(22):1827-30.

PubMed
[Fatigue fracture of the leg in runners].
[Fatigue fracture of the leg in runners].
Schweiz Z Sportmed. 1983 Sep ;31(3):95-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: