Abstract
Relapse of chronic T. brucei infections was completely prevented by treating with either diminazene aceturate (Berenil) at 40 mg/kg or suramin (Germanin) at 20 mg/kg followed by four doses of the 2-substituted 5-nitroimidazole (Fexinidazole) (Hoe 239). None of these drugs administered singly elicited 100% permanent cures although a high percentage of the mice were cured with four doses of Fexinidazole at 250 mg/kg. A single dose of 20 mg/kg suramin followed by four daily doses of 30 mg/kg Fexinidazole will effectively eliminate all the trypanosomes from the brains of chronically infected mice.
Publication types
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Comparative Study
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Antiprotozoal Agents / therapeutic use
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Chronic Disease
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Diminazene / analogs & derivatives
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Diminazene / therapeutic use
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Drug Therapy, Combination
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Female
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Mice
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Mice, Inbred Strains
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Nitroimidazoles / administration & dosage
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Nitroimidazoles / therapeutic use*
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Suramin / therapeutic use
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Trypanocidal Agents / therapeutic use
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Trypanosoma brucei brucei
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Trypanosomiasis, African / drug therapy*
Substances
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Antiprotozoal Agents
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Nitroimidazoles
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Trypanocidal Agents
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fexinidazole
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Suramin
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diminazene aceturate
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Diminazene