Science. 1983 Nov 11;222(4624):625-8.

Long-lived oxidants generated by human neutrophils: characterization and bioactivity.

Abstract

Human neutrophils were found to generate an unusual class of oxidants with a half-life of approximately 18 hours and with characteristics similar to, if not identical with, those of N-chloroamines. These neutrophil-derived N-chloroamines have sufficient oxidizing potential to attack sulfhydryl- or thioether-containing compounds and can react with both a methionine-containing chemotactic peptide and a plasma protease inhibitor. As judged by their stability and selective reactivity, the N-chloroamines generated by stimulated neutrophils may play an important role in the local and systemic regulation of inflammatory events in vivo.

PMID:: 6635660; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

Research Support, U.S. Gov't, P.H.S.

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Molecular Biology Databases

(L)-METHIONINE - HSDB

Supplemental Content

Save items

Related citations in PubMed

Chemotactic factors trigger their own oxidative inactivation by human neutrophils. [J Immunol. 1982]
Chemotactic factors trigger their own oxidative inactivation by human neutrophils.
Clark RA. J Immunol. 1982 Dec; 129(6):2725-8.
Chemotactic factor inactivation by stimulated human neutrophils mediated by myeloperoxidase-catalyzed methionine oxidation. [J Immunol. 1982]
Chemotactic factor inactivation by stimulated human neutrophils mediated by myeloperoxidase-catalyzed methionine oxidation.
Clark RA, Szot S. J Immunol. 1982 Apr; 128(4):1507-13.
Two neutrophil populations in human blood with different chemotactic activities: separation and chemoattractant binding. [Infect Immun. 1982]
Two neutrophil populations in human blood with different chemotactic activities: separation and chemoattractant binding.
Harvath L, Leonard EJ. Infect Immun. 1982 May; 36(2):443-9.
Review Structure-activity relationship of for-L-Met L-Leu-L-Phe-OMe analogues in human neutrophils. [Bioorg Chem. 2006]
Review Structure-activity relationship of for-L-Met L-Leu-L-Phe-OMe analogues in human neutrophils.
Cavicchioni G, Fraulini A, Falzarano S, Spisani S. Bioorg Chem. 2006 Oct; 34(5):298-318. Epub 2006 Aug 17.
Review A biological role for ascorbate in the selective neutralization of extracellular phagocyte-derived oxidants. [Ann N Y Acad Sci. 1987]
Review A biological role for ascorbate in the selective neutralization of extracellular phagocyte-derived oxidants.
Anderson R, Lukey PT. Ann N Y Acad Sci. 1987; 498:229-47.

See reviews... See all...

Cited by 44 PubMed Central articles

Antiadenoviral effects of N-chlorotaurine in vitro confirmed by quantitative polymerase chain reaction methods. [Clin Ophthalmol. 2010]
Antiadenoviral effects of N-chlorotaurine in vitro confirmed by quantitative polymerase chain reaction methods.
Uchio E, Inoue H, Kadonosono K. Clin Ophthalmol. 2010 Nov 19; 4:1325-9. Epub 2010 Nov 19.
L'inflammation dans la Mucoviscidose. [Mediators Inflamm. 1996]
L'inflammation dans la Mucoviscidose.
. Mediators Inflamm. 1996; 5(2):144-69.
Inflammation in cystic fibrosis. [Mediators Inflamm. 1996]
Inflammation in cystic fibrosis.
. Mediators Inflamm. 1996; 5(2):121-43.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound
PubChem chemical compound records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records. Multiple substance records may contribute to the PubChem compound record.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance
PubChem chemical substance records that cite the current articles. These references are taken from those provided on submitted PubChem chemical substance records.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Long-lived oxidants generated by human neutrophils: characterization and bioacti...
Long-lived oxidants generated by human neutrophils: characterization and bioactivity.
Science. 1983 Nov 11 ;222(4624):625-8.

PubMed
The Alzheimer's disease assessment scale: an instrument for assessing treatment ...
The Alzheimer's disease assessment scale: an instrument for assessing treatment efficacy.
Psychopharmacol Bull. 1983 ;19(3):448-50.

PubMed
Binding of labeled benzene metabolites to mouse liver and bone marrow.
Binding of labeled benzene metabolites to mouse liver and bone marrow.
Res Commun Chem Pathol Pharmacol. 1978 Apr ;20(1):191-4.

PubMed
Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus ...
Loss of pigmented dopamine-beta-hydroxylase positive cells from locus coeruleus in senile dementia of Alzheimer's type.
Neurosci Lett. 1983 Aug 19 ;39(1):95-100.

PubMed
Strategic factors in a lexical-decision task: evidence for automatic and attenti...
Strategic factors in a lexical-decision task: evidence for automatic and attention-driven processes.
Mem Cognit. 1983 Jul ;11(4):374-81.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: