J Clin Psychiatry. 1983 Sep;44(9):345-6.

Anorgasmia associated with imipramine but not desipramine: case report.

Abstract

A case of imipramine-induced orgasmic inhibition in a woman is reported. Desipramine, the metabolite of imipramine, did not produce this reaction. The ability of imipramine to block the CNS neuronal reuptake of serotonin (a property not shared by desipramine) is considered the probable pathophysiologic mechanism in the failure to achieve orgasm.

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