Abstract
Pathology, microbiology, and selected serum chemistries were evaluated in 144 male Fischer rats from 4 to 33 mo of age. The rats were reared and maintained under barrier conditions, which successfully excluded the introduction of major infectious disease agents throughout the entire study, including Mycoplasma pulmonis. A wide variety of pathology was found and tabulated, and many lesions were found to increase in severity and incidence with age. There was a high correlation of renal disease severity with increasing age, while alpha-1 globulin and cholesterol increased.
Publication types
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Adenoma, Chromophobe / pathology
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Aging*
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Alpha-Globulins / analysis
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Animals
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Blood Proteins / analysis
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Cardiovascular System / pathology
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Cholesterol / blood
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Germ-Free Life*
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Kidney / pathology
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Kidney Diseases / pathology
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Leukemia, Myeloid / pathology
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Leydig Cell Tumor / pathology
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Male
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Pituitary Neoplasms / pathology
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Rats
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Rats, Inbred F344 / physiology*
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Rats, Inbred Strains / physiology*
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Respiratory System / pathology
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Serum Albumin / analysis
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Specific Pathogen-Free Organisms*
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Spleen / pathology
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Testicular Neoplasms / pathology
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Testis / pathology
Substances
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Alpha-Globulins
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Blood Proteins
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Serum Albumin
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Cholesterol