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Radiat Res. 1983 Aug;95(2):421-6.

Are lesions induced by ionizing radiation direct blocks to DNA chain elongation?

Abstract

Ionizing radiation blocks DNA chain elongation in normal diploid fibroblasts but not in fibroblasts from patients with ataxia-telangiectasia, even though there are no differences in the damage induced between the two cell types. This difference suggests that radiation-induced lesions in DNA are not themselves blocks to chain elongation in ataxia cells and raises the possibility that in normal cells a mediator exists between DNA damage and chain termination.

PMID:
6611858
[PubMed - indexed for MEDLINE]
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