Identification of the receptor for antigen and major histocompatibility complex on human inducer T lymphocytes

Science. 1983 Dec 16;222(4629):1239-42. doi: 10.1126/science.6606228.

Abstract

Human T cell clones and monoclonal antibodies directed at their surface structures were used to define the receptor for the antigen and major histocompatibility complex on inducer T lymphocytes. The results indicated that the receptor is a single complex consisting of the monomorphic T3 molecule with a molecular weight of 20,000 to 25,000 and a clonotypic disulfide linked heterodimer Ti with a molecular weight of 90,000. Sepharose-bound monoclonal antibodies (anti-Ti4 or anti-T3) to the receptor could activate clonal proliferation and inducer function for B cell immunoglobulin secretion and thus substitute for the appropriate combination of major histocompatibility complex gene product and specific antigen.

Publication types

  • Research Support, U.S. Gov't, P.H.S.

MeSH terms

  • Antibodies, Monoclonal
  • B-Lymphocytes / immunology
  • Humans
  • Immunoglobulin G / biosynthesis
  • Lymphocyte Activation
  • Major Histocompatibility Complex*
  • Molecular Weight
  • Receptors, Antigen, T-Cell / analysis*
  • Receptors, Antigen, T-Cell / immunology
  • Receptors, Immunologic / analysis*
  • T-Lymphocytes / immunology*

Substances

  • Antibodies, Monoclonal
  • Immunoglobulin G
  • Receptors, Antigen, T-Cell
  • Receptors, Immunologic