Scand J Gastroenterol Suppl. 1984;104:3-14.

Clonogenic, stem and carcinogen-target cells in small intestine.

Abstract

The small intestine is an epithelial site which rarely undergoes carcinogenic transformation in spite of the fact that it is one of the most rapidly replacing tissues of the body. Some possible explanations for the low cancer incidence are discussed, with particular reference to the target cell population within the epithelium which is capable of carcinogenic transformation. It is proposed that the carcinogen target cells are the stem cells of the tissue and a possible defect which might lead to cancer is a slight alteration in the self-maintenance/differentiation probabilities in favour of self-maintenance.

PMID:: 6597548; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Medical

Stem Cells - MedlinePlus Health Information

Supplemental Content

Save items

Related citations in PubMed

Stem cell carcinoma in the small intestine of mice treated transplacentally with N-ethyl-N-nitrosourea: some quantitative and histological aspects. [Cancer Lett. 1984]
Stem cell carcinoma in the small intestine of mice treated transplacentally with N-ethyl-N-nitrosourea: some quantitative and histological aspects.
Oomen LC, van der Valk MA, Emmelot P. Cancer Lett. 1984 Nov; 25(1):71-9.
Review The small intestine as a model for evaluating adult tissue stem cell drug targets. [Cell Prolif. 2003]
Review The small intestine as a model for evaluating adult tissue stem cell drug targets.
Potten CS, Booth C, Hargreaves D. Cell Prolif. 2003 Jun; 36(3):115-29.
Review Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt. [Development. 1990]
Review Stem cells: attributes, cycles, spirals, pitfalls and uncertainties. Lessons for and from the crypt.
Potten CS, Loeffler M. Development. 1990 Dec; 110(4):1001-20.
Intestinal stem cells protect their genome by selective segregation of template DNA strands. [J Cell Sci. 2002]
Intestinal stem cells protect their genome by selective segregation of template DNA strands.
Potten CS, Owen G, Booth D. J Cell Sci. 2002 Jun 1; 115(Pt 11):2381-8.
A potent stimulator of small intestinal cell proliferation extracted by simple diffusion from intact irradiated intestine: in vitro studies. [Growth Factors. 1994]
A potent stimulator of small intestinal cell proliferation extracted by simple diffusion from intact irradiated intestine: in vitro studies.
Potten CS, Booth C, Chadwick CA, Evans GS. Growth Factors. 1994; 10(1):53-61.

See reviews... See all...

Cited by 2 PubMed Central articles

Review Bronchiolar progenitor cells. [Proc Am Thorac Soc. 2009]
Review Bronchiolar progenitor cells.
Chen H, Matsumoto K, Stripp BR. Proc Am Thorac Soc. 2009 Dec 1; 6(7):602-6.
Cell kinetics and polyamine enzymes in the intestinal mucosa of rats with azoxymethane induced tumours. [Int J Exp Pathol. 1994]
Cell kinetics and polyamine enzymes in the intestinal mucosa of rats with azoxymethane induced tumours.
Pizzi C, Pignata S, Calderopoli R, D'Agostino L, Tritto G, D'Adamo G, Esposito G, Daniele B, Mazzacca G, Bianco AR. Int J Exp Pathol. 1994 Oct; 75(5):305-11.

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Clonogenic, stem and carcinogen-target cells in small intestine.
Clonogenic, stem and carcinogen-target cells in small intestine.
Scand J Gastroenterol Suppl. 1984 ;104:3-14.

PubMed
Minnesota periodontal awareness television campaign.
Minnesota periodontal awareness television campaign.
Northwest Dent. 1984 Nov-Dec ;63(6):12-7.

PubMed
Activation of human factor IX (Christmas factor).
Activation of human factor IX (Christmas factor).
J Clin Invest. 1978 Jun ;61(6):1528-38.

PubMed
Vegetarian diet, blood pressure and cardiovascular risk.
Vegetarian diet, blood pressure and cardiovascular risk.
Aust N Z J Med. 1984 Aug ;14(4):439-43.

PubMed
Biochemical heterogeneity in glutathione synthetase deficiency.
Biochemical heterogeneity in glutathione synthetase deficiency.
J Clin Invest. 1978 Jun ;61(6):1417-20.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Clonogenic, stem and carcinogen-target cells in small intestine.

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 2 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information