Comput Biomed Res. 1984 Oct;17(5):471-80.

Combined analysis of genetic segregation and linkage under an oligogenic model.

Abstract

For traits with incomplete penetrance, simultaneous segregation analysis and linkage analysis may offer increased information. Since the numerical properties of the mixed model are a drawback in this more complicated analysis, a second locus is substituted for the polygenic component yielding a simpler and more tractable oligogenic model. While less realistic, the simpler model is not easily discriminated from the mixed model, particularly when used on affection data rather than quantitative traits. Calculations for combined linkage and segregation analysis are described for nuclear families with pointers to account for sampling scheme.

PMID:: 6593156; [PubMed - indexed for MEDLINE]

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Genetic Markers

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GM 17173/GM/NIGMS NIH HHS/United States

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Combined analysis of genetic segregation and linkage under an oligogenic model.

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

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Cited by 13 PubMed Central articles

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