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A molecular map of the human major histocompatibility complex class III region linking complement genes C4, C2 and factor B.
Four human complement genes, which have previously been mapped between HLA-D and HLA-B on chromosome 6, have now been aligned on a 98-kilobase (kb) section of the chromosome on the basis of four overlapping cosmid clones of genomic DNA. The C2 and factor B genes, less than 2 kb apart, are about 30 kb from two C4 genes separated from each other by about 10 kb.
PMID: 6559257 [PubMed - indexed for MEDLINE]
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Cited by 60 PubMed Central articles
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ReviewGenomic view of the evolution of the complement system.
Nonaka M, Kimura A.
Immunogenetics. 2006 Sep; 58(9):701-13. Epub 2006 Aug 9.
[Immunogenetics. 2006]
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Genetic sophistication of human complement components C4A and C4B and RP-C4-CYP21-TNX (RCCX) modules in the major histocompatibility complex.
Chung EK, Yang Y, Rennebohm RM, Lokki ML, Higgins GC, Jones KN, Zhou B, Blanchong CA, Yu CY.
Am J Hum Genet. 2002 Oct; 71(4):823-37. Epub 2002 Sep 11.
[Am J Hum Genet. 2002]
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Deficiencies of human complement component C4A and C4B and heterozygosity in length variants of RP-C4-CYP21-TNX (RCCX) modules in caucasians. The load of RCCX genetic diversity on major histocompatibility complex-associated disease.
Blanchong CA, Zhou B, Rupert KL, Chung EK, Jones KN, Sotos JF, Zipf WB, Rennebohm RM, Yung Yu C.
J Exp Med. 2000 Jun 19; 191(12):2183-96.
[J Exp Med. 2000]
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