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1: Prog Neuropsychopharmacol Biol Psychiatry. 1984;8(4-6):747-50.Links

Relative cataleptic potency of narcotic analgesics, including 3,6-dibutanoylmorphine and 6-monoacetylmorphine.

Tasker RA, Vander Velden PL, Nakatsu K.

Dose-response curves were constructed for duration of significant catalepsy in male Sprague-Dawley rats following i.p. administration of four established and two novel narcotic analgesics. The relative potency of the six drugs was levorphanol greater than monacetylmorphine greater than diacetylmorphine greater than dibutanoylmorphine greater than morphine greater than meperidine. Cataleptic potency correlated with analgesic potency for morphine, diacetylmorphine, and dibutanoylmorphine but not for monoacetylmorphine.

PMID: 6543399 [PubMed - indexed for MEDLINE]

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  • Meperidine (Demerol® Hydrochloride, Demerol® Hydrochloride Syrup)

    Meperidine is used to relieve moderate to severe pain. Meperidine is in a class of medications called narcotic analgesics, a group of pain medications similar to morphine. It works by changing the way the body senses pai...

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