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    Arzneimittelforschung. 1984;34(5):551-3.

    Stability indicating HPLC-method for the determination of econazole nitrate in cream and lotion formulations.

    Christinat R, Zulliger HW.

    Abstract

    A simple, fast HPLC-method for the determination of econazole nitrate in cream (Pevaryl, Pevisone) and lotion formulations (based on polyethylenic oleic glycerides and mono/di-stearic esters of ethylene- and polyethylene glycol) is described. The method is stability indicating as well as linear (range 5-15 mg econazole nitrate/g) and shows a good recovery (98.7-100.2%) and a good reproducibility (cv less than 1%, n = 10). The chromatographic separation is achieved on a RP-18 column using methanol/aqueous ammoniumcarbonate solution/tetrahydrofurane as the mobile phase. Quantification of the chromatograms is done by internal standard method using peak areas.

    PMID:
    6540569
    [PubMed - indexed for MEDLINE]

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