J Pharm Sci. 1984 Dec;73(12):1856-8.

Determination of the structure of a synthetic impurity in guaifenesin: modification of a high-performance liquid chromatographic method for phenylephrine hydrochloride, phenylpropanolamine hydrochloride, guaifenesin, and sodium benzoate in dosage forms.

Schieffer GW, Smith WO, Lubey GS, Newby DG.

Abstract

An impurity present in all commercial guaifenesin-containing dosage forms examined was isolated and identified as 2-(2-methoxyphenoxy) 1,3-propanediol (VI). The eluant of a previously developed stability-indicating liquid chromatographic method for phenylephrine hydrochloride (I), phenylpropanolamine hydrochloride (II), and guaifenesin (III) was modified to yield a better separation between phenylpropanolamine and the impurity. The method was expanded to include sodium benzoate (IV), a preservative found in some liquid formulations.

PMID:: 6527278; [PubMed - indexed for MEDLINE]

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Determination of the structure of a synthetic impurity in guaifenesin: modificat...
Determination of the structure of a synthetic impurity in guaifenesin: modification of a high-performance liquid chromatographic method for phenylephrine hydrochloride, phenylpropanolamine hydrochloride, guaifenesin, and sodium benzoate in dosage forms.
J Pharm Sci. 1984 Dec ;73(12):1856-8.

PubMed
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[Effect of sex steroids in vivo and in vitro on the binding of uric acid to plasma proteins].
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Determination of the structure of a synthetic impurity in guaifenesin: modification of a high-performance liquid chromatographic method for phenylephrine hydrochloride, phenylpropanolamine hydrochloride, guaifenesin, and sodium benzoate in dosage forms.

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