Biochem Biophys Res Commun. 1984 Dec 28;125(3):1046-52.

Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition.

Abstract

Lipid peroxidation in rat brain mitochondria was induced by NADH in the presence of ADP and FeCl3. CV-2619 inhibited the lipid peroxidation in a concentration-dependent manner; the concentration giving 50% inhibition (IC50) was 84 microM. In addition, the inhibitory effect of CV-2619 was strongly enhanced by adding substrates of mitochondrial respiration; when succinate, glutamate, or succinate plus glutamate was added, the IC50 of CV-2619 was changed to 1.1, 10, or 0.5 microM, respectively. Metabolites of CV-2619 also inhibited the lipid peroxidation. The inhibitory effect of CV-2619 on mitochondrial lipid peroxidation disappeared when TTFA, an inhibitor of complex II in mitochondrial respiratory chain, was added. The results indicate that in mitochondria CV-2619 is changed to its reduced form which inhibits lipid peroxidation.

PMID:: 6517932; [PubMed - indexed for MEDLINE]

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Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochon...
Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition.
Biochem Biophys Res Commun. 1984 Dec 28 ;125(3):1046-52.

PubMed
[Effects of 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (CV-261...
[Effects of 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (CV-2619) on adriamycin-induced ECG abnormalities and myocardial energy metabolism in spontaneously hypertensive rats].
Nihon Yakurigaku Zasshi. 1982 Oct ;80(4):307-15.

PubMed
[Effects of idebenone (CV-2619) on neurological deficits, local cerebral blood f...
[Effects of idebenone (CV-2619) on neurological deficits, local cerebral blood flow, and energy metabolism in rats with experimental cerebral ischemia].
Nihon Yakurigaku Zasshi. 1984 Sep ;84(3):303-9.

PubMed
Inhibitory effect of idebenone (CV-2619), a novel compound, on vascular lesions ...
Inhibitory effect of idebenone (CV-2619), a novel compound, on vascular lesions in hypertensive rats.
Jpn J Pharmacol. 1984 Nov ;36(3):291-9.

PubMed
[Effects of 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (CV-261...
[Effects of 2,3-dimethoxy-5-methyl-6-(10'-hydroxydecyl)-1,4-benzoquinone (CV-2619) on myocardial energy metabolism in the hypertrophied heart of spontaneously hypertensive rats].
Nihon Yakurigaku Zasshi. 1982 Oct ;80(4):299-306.

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Inhibition of lipid peroxidation by a novel compound (CV-2619) in brain mitochondria and mode of action of the inhibition.

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