An investigation was made into the incidence of cardiovascular diseases in the Dutch viscose rayon industry. The first part of the article discusses a further study, complementary to a pilot study conducted in 1974, into the distribution of cardiovascular cases among the various departments of a rayon plant. No differences in the frequency of cardiovascular cases in departments with and departments without CS2 were observed. The second part deals with a case-control study in which the total number of patients per plant was matched with comparable individuals not suffering from cardiovascular disease. Here, too, it was not possible to demonstrate a significant correlation between CS2 exposure and cardiovascular diseases. The third part describes a cohort study. Three cohorts were formed: (1) a cohort of shift workers exposed to CS2; (2) a cohort of shift workers not exposed to CS2; and, (3) a cohort of non-shift workers not exposed to CS2. With a three-year interval, these cohorts were examined twice for cardiovascular diseases, with reference to a checklist of 39 variables. Again, no significant differences between the cohorts could be shown to exist.