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    Hum Genet. 1984;68(1):70-2.

    A unique electrophoretic slow-moving glucose 6-phosphate dehydrogenase variant (G6PD Asahikawa) with a markedly acidic pH optimum.

    Takizawa T, Fujii H, Takegawa S, Takahashi K, Hirono A, Morisaki T, Kanno H, Oka R, Yoshioka H, Miwa S.

    Abstract

    A new glucose 6-phosphate dehydrogenase (G6PD) variant associated with chronic nonspherocytic hemolytic anemia was discovered in Japan. The patient showed hemolytic crises after upper respiratory infections. The enzyme activity was about 3.8% of the normal. The partially purified enzyme revealed slow anodal electrophoretic mobility, high Km NADP, marked thermal-instability, and increased affinity for a substrate analogue (deamino-NADP). A particular characteristic of this enzyme was a biphasic pH curve with a greatly increased activity at low pH values. From these results, this variant was clearly different from hitherto observed G6PD variants, and was designated G6PD Asahikawa.

    PMID:
    6500558
    [PubMed - indexed for MEDLINE]

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