Effect of phencyclidine (PCP) on blood pressure and catecholamine levels in discrete brain nuclei

Brain Res. 1984 Nov 12;321(2):315-8. doi: 10.1016/0006-8993(84)90184-7.

Abstract

PCP (10 mg/kg, s.c.) causes hypertension that is associated with decrease or tendency to decrease the levels of epinephrine and norepinephrine in the hypothalamus and the brainstem regions. If this represents a decreased catecholaminergic activity, then this may enhance sympathetic activity and contribute to the PCP-induced hypertension.

Publication types

  • Comparative Study

MeSH terms

  • Animals
  • Blood Pressure / drug effects*
  • Brain Chemistry / drug effects*
  • Brain Stem / analysis
  • Catecholamines / analysis*
  • Caudate Nucleus / analysis
  • Dopamine / analysis
  • Epinephrine / analysis
  • Female
  • Hypothalamus / analysis
  • Norepinephrine / analysis
  • Phencyclidine / pharmacology*
  • Rats
  • Rats, Inbred Strains

Substances

  • Catecholamines
  • Phencyclidine
  • Dopamine
  • Norepinephrine
  • Epinephrine