Age Ageing. 1984 Sep;13(5):313-6.

Drug induction of hepatic enzymes in the elderly.

Abstract

Previous workers have suggested that hepatic enzyme induction by drugs does not occur in the elderly. We have studied the effect of a potent enzyme inducer--glutethimide--on a group of nine patients over the age of 70 years, using antipyrine clearance as a measure of hepatic drug metabolism. After six days treatment with glutethimide, antipyrine clearance rose from 22.8 +/- 4.5 ml/min to 38.3 +/- 7.6 ml/min (P less than 0.001). The results suggest that the elderly are at risk for the full range of drug interactions due to hepatic microsomal enzyme induction.

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The features of hepatic enzyme induction with glutethimide in man. [Br J Clin Pharmacol. 1978]
The features of hepatic enzyme induction with glutethimide in man.
Jackson L, Homeida M, Roberts CJ. Br J Clin Pharmacol. 1978 Dec; 6(6):525-8.
Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease. [Eur J Clin Pharmacol. 1979]
Enhancement of hepatic drug metabolism by glutethimide in patients with liver disease.
Farrell GC, Cooksley WG, Powell LW. Eur J Clin Pharmacol. 1979 Sep; 16(2):113-7.
Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease. [Gastroenterology. 1981]
Relationship between metabolic clearance rate of antipyrine and hepatic microsomal drug-oxidizing enzyme activities in humans without liver disease.
Vuitton D, Miguet JP, Camelot G, Delafin C, Joanne C, Bechtel P, Gillet M, Carayon P. Gastroenterology. 1981 Jan; 80(1):112-8.
Review [Enzyme induction in the liver changes drug activity]. [Med Klin. 1980]
Review [Enzyme induction in the liver changes drug activity].
Greim H. Med Klin. 1980 Sep 26; 75(20):709-12.
Review [The use of the antipyrine test for studying microsomal drug oxidation]. [Farmakol Toksikol. 1990]
Review [The use of the antipyrine test for studying microsomal drug oxidation].
Viktorov AP, Rybak AT. Farmakol Toksikol. 1990 Jan-Feb; 53(1):74-7.

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Cited by 1 PubMed Central article

Review Age-related changes in pharmacokinetics and pharmacodynamics: basic principles and practical applications. [Br J Clin Pharmacol. 2004]
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